Noho — The Hangover Defense, owned by Dolce Bevuto, is formulated to hydrate the human body with the nutrients it loses while drinking alcohol, thus preventing a hangover, the company says. Adults are instructed to drink a 2-ounce bottle of Noho before their first alcohol beverage to pump their bodies full of the nutrients needed to prevent a hangover. Each bottle contains 4 calories and retails for $3.49.